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Reversal of known pathophysiological disorder, not simply reducing hyperglycemia.
It is now recognized that b cell faailure occurs much ealier and is more severe than previously thought.
So we start treatment much early to prevent progressive b cell failure.
Multiple drugs in combination is required to correct the multiple pathophysiological defect.
To Prevent progressive b-cell failure.
To improve insulin sensitivity.
To treat the multiple patho-physiological defect.
Good metabolic control.
To prevent development of progression of diabetes complication.
To control hyperglycemia for life without insulin.
To improve quality of life.
By 2030 will be 30%
By end of century IT will be 100%
FBG > 126
PPBG > 200
2 hrs PG(in GIT
HBAIC > 6.5